Inhibiting CYP17 causes a compensatory increase in ACTH, leading to mineralocorticoid excess. Low-dose prednisone replaces lost cortisol and prevents severe hypertension and fluid retention.

It must be taken on an empty stomach?at least 1 hour before or 2 hours after food. Taking it with food can significantly increase absorption, leading to toxic side effects.

Serum potassium levels must be closely monitored, as drug-induced mineralocorticoid excess can cause dangerous hypokalemia (low potassium).

It can cause severe drug-induced hepatotoxicity. Liver function tests (LFTs) are typically required every two weeks for the first three months of treatment.

No, it is strictly indicated for male prostate cancer and can cause severe fetal harm if a pregnant woman is accidentally exposed to the drug particles.

By suppressing testosterone to near-zero levels, long-term use can accelerate bone loss, increasing the risk of osteoporosis and bone fractures.

Yes, due to fluid retention risks, it can worsen pre-existing congestive heart failure, ischemic heart disease, or cause atrial fibrillation.

Oncologists monitor regular declines in Prostate-Specific Antigen (PSA) blood markers alongside serial imaging scans.

No, the tablets should be swallowed whole with a glass of water to preserve their release properties and prevent unintended exposure to handlers.

The standard adult dose is 1,000mg daily, which requires taking four 250mg tablets together as a single dose on an empty stomach.