Treatment of acute, uncomplicated malaria infections caused by Plasmodium falciparum. It is used for treatment, not for prevention (prophylaxis).

Artemether is a fast-acting component that quickly reduces the parasite load in the blood during the first few hours. Lumefantrine has a longer half-life; it stays in the system longer to clear any remaining parasites and prevent the infection from returning. Together, they interfere with the parasite's ability to detoxify heme (a byproduct of digesting human red blood cells), effectively "poisoning" the malaria parasite.

Common: Headache, dizziness, loss of appetite, and joint/muscle pain. Gastrointestinal: Nausea, vomiting, or abdominal pain. Cardiac: In rare cases, it can affect heart rhythm (QT prolongation). Neurological: Fatigue or sleep disturbances.