Management of newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), gastrointestinal stromal tumors (GIST), and hypereosinophilic syndrome.
Management of newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), gastrointestinal stromal tumors (GIST), and hypereosinophilic syndrome.
Functions as a selective tyrosine kinase inhibitor (TKI). It specifically targets and binds to the ATP-binding pocket of the BCR-ABL fusion protein, blocking downstream signaling pathways that drive uncontrolled leukemic cell proliferation.
Fluid retention (periorbital and peripheral edema), muscle cramps, nausea, diarrhea, fatigue, rash, and minor neutropenia.
Imatinib targets the abnormal tyrosine kinase enzyme produced by the BCR-ABL fusion gene, commonly referred to as the Philadelphia chromosome.
Imatinib inhibits PDGFR (platelet-derived growth factor receptor), which alters interstitial fluid pressure, frequently manifesting as puffiness around the eyes or ankles.
Take the tablet with a main meal and a large glass of water to minimize the risk of severe gastrointestinal lining irritation.
No. Grapefruit juice inhibits the CYP3A4 enzyme, which can significantly raise Imatinib levels in the blood, increasing toxicity risks.
Complete Blood Counts (CBC) and liver function tests (LFTs) should be conducted monthly to detect myelosuppression and hepatotoxicity early.
It is a highly effective long-term maintenance therapy that induces deep molecular remission, though most patients must take it continuously to prevent relapse.
Ensure adequate hydration. Calcium, magnesium, or tonic water supplements can be discussed with your oncologist for symptomatic relief.
Yes. Avoid high-dose paracetamol/acetaminophen due to overlapping hepatotoxicity profiles, and avoid NSAIDs if platelet counts are depressed.
Take the missed dose as soon as possible, unless the next scheduled dose is nearby. Never double the dose to compensate for a missed one.
No, it causes significant fetal harm. Effective birth control must be strictly practiced throughout the entire duration of therapy.