Ketoconazole is a potent antifungal medication used to treat serious fungal infections like histoplasmosis, blastomycosis, and severe skin or yeast infections that do not respond to topical creams.

It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. By creating 'holes' in the cell membrane, it causes the fungal cells to leak and die.

Yes, it is best to take Ketoconazole with a meal. This helps increase the absorption of the drug and reduces common side effects like nausea or stomach upset.

No. Ketoconazole requires stomach acid to dissolve and work properly. Avoid taking antacids, H2 blockers, or PPIs (like Omeprazole) at the same time. If necessary, take Ketoconazole at least 2 hours before these medications.

Ketoconazole carries a risk of liver toxicity. It is generally only prescribed when other antifungal treatments are not suitable, and doctors often perform regular liver function tests (LFTs) during treatment.

Common side effects include nausea, vomiting, abdominal pain, headache, and dizziness. Some men may also experience breast swelling (gynecomastia) due to its effect on certain hormones.

It is strictly advised to avoid alcohol while taking Ketoconazole, as the combination significantly increases the risk of severe liver damage.

In high doses, Ketoconazole can block the production of cortisol in the adrenal glands, making it an off-label treatment option for managing excess cortisol levels.

Stop taking the medication immediately and contact your doctor. Yellowing of the eyes or skin (jaundice) is a serious sign of liver distress.

'I.P.' stands for Indian Pharmacopoeia, indicating that the medicine meets the official quality, purity, and strength standards required in India.