Type 2 Diabetes with Dyslipidemia: For patients whose blood sugar is high and who also have high levels of triglycerides or low HDL ("good") cholesterol. Hypertriglyceridemia: Specifically targeting high fat levels in the blood to prevent complications like pancreatitis. Metabolic Syndrome: Helping to manage the cluster of conditions that increase the risk of heart disease and stroke.
This tablet works in both the liver and the bloodstream: Metformin (ER): It primarily acts on the liver to reduce the production of glucose. It also increases the sensitivity of your muscle cells to insulin, allowing them to use sugar more effectively. The Extended Release (ER) version ensures the drug enters the system gradually, reducing gastrointestinal distress. Fenofibrate: It activates a specific receptor in the body (PPAR-alpha) that increases the breakdown of fats. It specifically lowers Triglycerides and VLDL levels while helping to moderately increase HDL (good cholesterol). This helps clear "fatty" blood, which is common in diabetic patients.
Common Side Effects Nausea, bloating, or diarrhe Metallic taste in the mouth Stomach pain Loss of appetite Serious / Rare Side Effects Muscle pain or weakness (Myopathy) Liver enzyme elevation Lactic Acidosis (extremely rare) Gallstones (long-term use)
Diabetes often goes hand-in-hand with high triglycerides. This combination simplifies your treatment by controlling both blood glucose and blood fats simultaneously.
It is best taken with a meal, usually dinner. Taking it with food improves the absorption of Fenofibrate and reduces the stomach upset often caused by Metformin.
No. Alcohol increases the risk of Lactic Acidosis from Metformin and can raise triglyceride levels, defeating the purpose of taking Fenofibrate.
Contact your doctor immediately. Fibrates can occasionally cause muscle damage, especially if you are also taking other cholesterol medicines like Statins.
No. The ER tablet is designed to release medicine slowly. Crushing it can cause a 'dose dump,' leading to severe side effects or toxicity.
Metformin is often associated with modest weight loss or weight neutrality. Fenofibrate does not significantly affect body weight.
Yes. Your doctor will likely order periodic blood tests to check your liver enzymes, as Fenofibrate can occasionally affect liver health.
Metformin and Fenofibrate are both processed by the kidneys. If you have moderate to severe kidney impairment, this medication may not be suitable for you.
Take it as soon as you remember with food. If it is almost time for your next dose, skip the missed one. Do not double the dose.
No. This medication works best when paired with a low-fat, low-sugar diet and regular physical activity.
