Chronic Low Back Pain: Especially when nerve compression (sciatica) is involved. Post-Surgical Pain: To manage both nerve sensitivity and tissue inflammation. Fibromyalgia: For widespread muscle pain and nerve sensitivity. Severe Osteoarthritis: When joint inflammation triggers secondary nerve pain.

Pregabalin (PR): It binds to the $\alpha_2\delta$ site of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters (like glutamate), essentially "calming" overexcited nerves that send pain signals.Etoricoxib: It selectively inhibits the COX-2 enzyme, which is responsible for making prostaglandins at the site of injury. By blocking COX-2, it reduces swelling, redness, and inflammatory pain without as much stomach irritation as older NSAIDs.

Neurological: Dizziness, somnolence (sleepiness), and blurred vision. Physical: Peripheral edema (swelling of hands/feet) and weight gain. Gastrointestinal: Heartburn, nausea, or constipation. Cardiovascular: Potential increase in blood pressure.