Irritable Bowel Syndrome with Diarrhea (IBS-D): To reduce bloating and urgency. Hepatic Encephalopathy: To prevent brain dysfunction in patients with liver failure by reducing ammonia-producing bacteria. Traveler?s Diarrhea: Caused by non-invasive strains of E. coli. SIBO (Small Intestinal Bacterial Overgrowth): To clear excess bacteria from the small intestine.

It binds to the bacterial enzyme DNA-dependent RNA polymerase, which prevents the bacteria from making proteins and multiplying. Because less than 1% of the drug is absorbed into the blood, it exerts its full force directly on the bacteria living in the intestines without causing many systemic side effects.

Common: Flatulence (gas), abdominal pain, urgency to empty bowels, and nausea. Occasional: Headache, dizziness, or peripheral edema (swelling of hands/feet). Serious (Rare): C. difficile-associated diarrhea (severe persistent diarrhea).