Type 2 Diabetes Mellitus: Primarily used when diet, exercise, and Metformin alone do not provide sufficient blood sugar control. Glycemic Control: Helps lower both fasting and post-meal blood glucose levels.

Metformin works in three ways: it reduces the amount of sugar your liver produces, decreases the amount of sugar your intestines absorb, and makes your body more sensitive to its own insulin. Sitagliptin works by preventing the breakdown of "incretin" hormones. These hormones tell the pancreas to release more insulin when blood sugar is high and signal the liver to stop producing excess sugar. Because it only triggers insulin when sugar is high, it has a lower risk of "sugar crashes."

Digestive: Nausea, diarrhea, stomach upset, or a metallic taste in the mouth (common with Metformin). Respiratory: Stuffy or runny nose, sore throat (common with Sitagliptin). General: Headache or mild swelling of the hands/legs. Serious (Rare): Pancreatitis (severe abdominal pain) or Lactic Acidosis (excess acid in the blood).